Catlab Reports Bulletin

The Catlab Reports Bulletin is published monthly. Until the publication of the Catlab website, it was mailed electronically to our clients. It consists of a monograph related with laboratory topics. Each month it addresses a different area of Catlab; the topics can be more specific (concrete diagnostic techniques) or deal with more generic aspects (Quality, Management, …).

Bulletin Nº54 - November

EXTRA-ANALYTIC - Application of pre-analytical program PAQC
The PAQC BD Diagnostics (Becton Dickinson) is an application program to evaluate the extraction processes and preanalytical part within the laboratory. With the results, you can make a "benchmarking" between the different centers.

Bulletin Nº53 - October

URGENT CARE - Natriuretic Peptides
Natriuretic peptides were discovered over 25 years ago. Now there are 2 of them; BNP and NT-proBNP that have begun to include in Emergency Laboratories requests; and which have meaning useful to rule out heart failure in patients with acute dyspnea and no conclusive diagnosis.

Bulletin Nº52 - September

The determination of the HLA-B * 5701 is the first pharmacogenetic test in the context of treatment of HIV-1. The haplotype HLA-B * 5701 significantly predicted the risk of hypersensitivity reaction to Abacavir (ABC), which is currently the antiretroviral reverse transcriptase inhibitor, preferentially used to treat HIV-1.

Bulletin Nº51 - June 2014

Array-CGH technology detects dose changes (copy number changes or CNV), along the whole genome. The technique is based on the competitive hybridization between a reference DNA and a patient DNA.

Bulletin Nº50 - May 2014

IMMUNOLOGY - Identification and utility of onconeuronal antibodies
Paraneoplastic Neurological Syndrome (SNPN) is an heterogeneous group of neurological disorders that present some of the cancer patients. Developing the autoimmune response to tumor antigens affect the nervous system. The SNPN considered preceding forms of cancer, and thus may help predict a hidden cancer.

Bulletin Nº49 - April 2014

BIOCHEMISTRY - Bone remodeling biochemical markers
Biochemical markers of bone remodeling measured the activity of osteoblasts and osteoclasts, from the determination of substances produced by bone cells and the determination of the bone components that is shed into the blood circulation during its destruction or formation.

Bulletin Nº48 - March 2014

CITOMETRY - Celiac disease and flux citometry
The disease affects 1% of the population, but is known, is very underdiagnosed because it is often asymptomatic and symptoms occur discontinuously and with a highly variable clinical spectrum. The cytometric study is based on the immunophenotyping identification and quantification of intraepithelial lymphocytes (IELs) of the duodenal mucous.

Bulletin Nº47 - February 2014

MOLECULAR BIOLOGY - Change of method in celiac disease molecular study
Celiac disease is a chronic inflammatory bowel disease that affects from 1 to 3% of the Western population. At the molecular level, is associated with the HLA genes. From December 2013 we incorporated a new equipment that allows us to make a complete study of the two genetic regions associated with celiac disease (HLA-DQA/HLA-DQB). This equipment is designed to work with reverse hybridization technique adapted to a microarray plate, and also allows us to determine if these alleles are in heterozygous or homozygous state.

Bulletin Nº46 - January 2014

CYTOGENETICS - New method of noninvasive prenatal screening. Study of fetal aneuploidy in maternal blood
Based on the study of circulating fetal DNA in maternal blood, new techniques have been developed for prenatal aneuploidy screening with high sensitivity and specificity.

Bulletin Nº45 - December 2013

QUALITY - Measure customer satisfaction
During the years 2010-2012, Catlab has made ​​a plan for measuring customer satisfaction, a survey of 10 questions related to the laboratory, targeting Clinicians.